Which manifestation is most likely with Clostridium difficile infection?

Which manifestation is most likely with Clostridium difficile infection?

• A. Fever
• B. Vomiting
• C. Chills
• D. Diarrhea

Answer: (D)

Clostridium difficile infection most often presents with diarrhea because its toxins damage the lining of the colon and trigger inflammation that drives water and electrolyte loss into the stool. The toxins A and B disrupt enterocytes and tight junctions, causing increased secretion and impaired absorption, so you typically see three or more loose stools in a 24-hour period. Fever and abdominal cramps can occur, but diarrhea is the hallmark feature, while vomiting and chills are less common.

Clostridium difficile infection most often presents with diarrhea because its toxins damage the lining of the colon and trigger inflammation that drives water and electrolyte loss into the stool. The toxins A and B disrupt enterocytes and tight junctions, causing increased secretion and impaired absorption, so you typically see three or more loose stools in a 24-hour period. Fever and abdominal cramps can occur, but diarrhea is the hallmark feature, while vomiting and chills are less common.